Norway’s Karianne Giller Fleten, Christin Lund-Andersen, Annette Torgunrud and Kjersti Flatmark have published a new paper that looks into the individual efficacy of four drug therapies on peritoneal metastases in mouse-human xenograft models: oxaliplatin, irinotecan, cabazitaxel, and regorafenib and capecitabine. The results support the continued exploration of intraperitoneal treatment protocols for peritoneal metastases with oxaliplatin remaining and cabazitaxel emerging as the most interesting candidates for further studies. You can read the new paper here.
EuroPMP’s own Professor Kjersti Flatmark and colleagues have published new findings showing that the use of mitomycin C with intraperitoneal chemotherapy (IPEC) during cytoreductive surgery doubled survival times and reduced tumour growth in a xenograft model when compared to surgery alone. In a signet ring cell model of high-grade PMP, three different methods were tested: normal cytoreductive surgery (CRS), CRS and intraperitoneal chemotherapy of normal temperature and CRS with hyperthermic IPEC (HIPEC). After examination of the methods, it was found that tumour weights were noticeably lower in the groups receiving either IPEC or HIPEC when compared to cytoreductive surgery alone. While more testing will be needed to confirm this finding…