Researchers Christin Lund-Andersen, Annette Torgunrud, Karianne Giller-Fleten (shared first-authors) and P.I. Kjersti Flatmark have published an extensive review article looking at the use of high-throughput -omics analysis in the search for a cure for peritoneal metastases from colorectal cancer (PM-CRC) and pseudomyxoma peritonei (PMP). The study looked at molecular approaches including genomic, transcriptomic and proteomic analyses, and tumour enrichment strategies to determine whether there are any patterns in the data that could potentially assist in the management of patients with PM-CRC or PMP. The findings indicate that while there are many potential areas to focus on in the research environment, there is a strong indication that the best way forward must necessarily involve international collaboration. Networks such as the EuroPMP COST Action are working to coordinate research efforts through the promotion of standardised reporting of collected samples as well as standardised processing and analysis to allow comparison between studies and increase both the size of cohorts, and maximise the use of very limited resources.
You can read this incisive paper at this link.
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| Christin Lund-Andersen | Karianne Giller-Fleten | Annette Torgunrud |